Neandertal origin of genetic variation at the cluster of OAS immunity genes.

@article{Mendez2013NeandertalOO,
  title={Neandertal origin of genetic variation at the cluster of OAS immunity genes.},
  author={Fernando Luis Mendez and Joseph Watkins and Michael F. Hammer},
  journal={Molecular biology and evolution},
  year={2013},
  volume={30 4},
  pages={
          798-801
        }
}

• Fernando Luis Mendez, Joseph Watkins, Michael F. Hammer
• Published 2013 in Molecular biology and evolution
• DOI:10.1093/molbev/mst004

Analyses of ancient DNA from extinct humans reveal signals of at least two independent hybridization events in the history of non-African populations. To date, there are very few examples of specific genetic variants that have been rigorously identified as introgressive. Here, we survey DNA sequence variation in the OAS gene cluster on chromosome 12 and provide strong evidence that a haplotype extending for ~185 kb introgressed from Neandertals. This haplotype is nearly restricted to Eurasians… CONTINUE READING

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