Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex.

@article{Hammond2014Ndfip1IR,
  title={Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex.},
  author={Vicki E. Hammond and Jenny Margaret Gunnersen and C Goh and Ley-Hian Low and Tomoko Hyakumura and Michelle M Tang and Joanne M. Britto and Ulrich Putz and J Howitt and S S Tan},
  journal={Cerebral cortex},
  year={2014},
  volume={24 12},
  pages={3289-300}
}
Ubiquitin ligases of the Nedd4 family are important for axon and dendrite development, but little is known about their adaptor, Nedd4 family-interacting protein 1 (Ndfip1), that is responsible for their enzymatic activation. To study the function of Ndfip1 in cortical development, we generated a conditional knock-out (conditional KO) in neurons. The Ndfip1 conditional KO mice were viable; however, cortical neurons in the adult brain exhibited atrophic characteristics, including stunted… CONTINUE READING

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