Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion

@article{Chaki2019NckAP,
  title={Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion},
  author={S. P. Chaki and R. Barhoumi and G. Rivera},
  journal={Cancer Medicine},
  year={2019},
  volume={8},
  pages={7385 - 7398}
}
Podosomes are membrane‐bound adhesive structures formed by actin remodeling. They are capable of extracellular matrix (ECM) degradation, which is a prerequisite for cancer cell invasion and metastasis. The signaling mechanism of podosome formation is still unknown in cancer. We previously reported that Nck adaptors regulate directional cell migration and endothelial lumen formation by actin remodeling, while deficiency of Nck reduces cancer metastasis. This study evaluated the role of Nck… Expand
Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression
Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology
Adaptor proteins: Flexible and dynamic modulators of immune cell signalling
Endocrinology of the Aging Prostate: Current Concepts

References

SHOWING 1-10 OF 79 REFERENCES
Biogenesis of podosome rosettes through fission
Signaling inputs to invadopodia and podosomes
ECM degradation assays for analyzing local cell invasion.
Podosome-mediated matrix resorption and cell motility in vascular smooth muscle cells.
Actin remodeling by Nck regulates endothelial lumen formation
...
1
2
3
4
5
...