Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.

@article{Hagenow2009Ncf1associatedRO,
  title={Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.},
  author={Kristin Hagenow and Kyra A. Gelderman and Malin Hultqvist and Patrick Merky and Johan B{\"a}cklund and Oliver Frey and Thomas Kamradt and Rikard Holmdahl},
  journal={Journal of immunology},
  year={2009},
  volume={183 2},
  pages={874-81}
}
Reactive oxygen species (ROS) are important in the immune defense against invading pathogens, but they are also key molecules in the regulation of inflammatory reactions. Low levels of ROS production due to a polymorphism in the neutrophil cytosolic factor 1 (Ncf1) gene are associated with autoimmunity and arthritis severity in mouse models induced with adjuvant. We established an adjuvant-free arthritis model in which disease is induced by injection of the autoantigen collagen type II (CII… CONTINUE READING

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