Nbs1 is required for ATR-dependent phosphorylation events.

  title={Nbs1 is required for ATR-dependent phosphorylation events.},
  author={Tom Stiff and Caroline P Reis and Gemma K. Alderton and Lisa J Woodbine and Mark O'Driscoll and Penny A Jeggo},
  journal={The EMBO journal},
  volume={24 1},
Nijmegen breakage syndrome (NBS) is characterised by microcephaly, developmental delay, characteristic facial features, immunodeficiency and radiosensitivity. Nbs1, the protein defective in NBS, functions in ataxia telangiectasia mutated protein (ATM)-dependent signalling likely facilitating ATM phosphorylation events. While NBS shares overlapping characteristics with ataxia telangiectasia, it also has features overlapping with ATR-Seckel (ATR: ataxia-telangiectasia and Rad3-related protein… CONTINUE READING


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