Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain.

@article{Chien1993NavigationalEM,
  title={Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain.},
  author={C B Chien and Dr. Gary E. Rosenthal and William A. Harris and Christine E Holt},
  journal={Neuron},
  year={1993},
  volume={11 2},
  pages={237-51}
}
We have developed an exposed brain preparation for observing growth cone pathfinding behavior while performing in vivo pharmacological manipulations, and we used it to test whether Xenopus retinal growth cones need filopodia to navigate. Time-lapse video observation showed that cytochalasin B acted quickly and reversibly when applied; cytochalasin B-treated growth cones lacked filopodia, but had active lamellipodia and continued to advance slowly. Whereas normal retinotectal axons visualized… CONTINUE READING
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