Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.

  title={Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.},
  author={Lawrence N. Kwong and Michael A. Davies},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 19},
Melanoma is entering into an era of combinatorial approaches to build upon recent clinical breakthroughs achieved by novel single-agent therapies. One of the leading targets to emerge from the growing understanding of the molecular pathogenesis, heterogeneity, and resistance mechanisms of melanomas is the phosphoinositide 3-kinase (PI3K)-AKT pathway. Multiple genetic and epigenetic aberrations that activate this pathway have been identified in melanomas de novo and in acquired resistance models… CONTINUE READING
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