Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.

@article{Kwong2013NavigatingTT,
  title={Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.},
  author={Lawrence N. Kwong and Michael A. Davies},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 19},
  pages={5310-9}
}
Melanoma is entering into an era of combinatorial approaches to build upon recent clinical breakthroughs achieved by novel single-agent therapies. One of the leading targets to emerge from the growing understanding of the molecular pathogenesis, heterogeneity, and resistance mechanisms of melanomas is the phosphoinositide 3-kinase (PI3K)-AKT pathway. Multiple genetic and epigenetic aberrations that activate this pathway have been identified in melanomas de novo and in acquired resistance models… CONTINUE READING
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Targeting BRAF and PI30-kinase signaling for therapy of melanoma

  • M McMahon, MD Thakur, V Marsh, J Silva, AS Landman, M Deuker
  • Proceedings of the Annual Meeting of the American…
  • 2013
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