Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

@inproceedings{Udit2017Nav18NA,
  title={Nav1.8 neurons are involved in limiting acute phase responses to dietary fat},
  author={Swalpa Udit and Michael E. Burton and Joseph M Rutkowski and Syann Lee and Angie Lynn Bookout and Philipp E Scherer and Joel K Elmquist and Laurent Gautron},
  booktitle={Molecular metabolism},
  year={2017}
}
OBJECTIVE AND METHODS Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. RESULTS While mice lacking sensory neurons displayed no differences in body weight, food intake, energy expenditure, or body composition compared to controls on chow diet, ablated mice developed an exaggerated inflammatory response to high… CONTINUE READING
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