Nature versus nurture in glioblastoma: microenvironment and genetics can both drive mesenchymal transcriptional signature.

@article{Orr2012NatureVN,
  title={Nature versus nurture in glioblastoma: microenvironment and genetics can both drive mesenchymal transcriptional signature.},
  author={Brent A. Orr and Charles G. Eberhart},
  journal={The American journal of pathology},
  year={2012},
  volume={180 5},
  pages={
          1768-71
        }
}
Glioblastomas (GBMs) are the most common malignant brain tumors, but they are currently incurable. It is hoped that targeted therapies may prove effective in improving survival. Indeed, efforts to integrate multimodal molecular and clinical data for brain tumors have begun to yield a clearer picture of these aggressive neoplasms. The Cancer Genome Atlas (TCGA) and the Repository of Molecular Brain Neoplasia Data (REMBRANDT) both support numerous data sets for mRNA and miRNA expression, DNA copy… CONTINUE READING
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