Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis.

@article{Turjman1981NatureOT,
  title={Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis.},
  author={N A Turjman and Padmanabhan P. Nair},
  journal={Cancer research},
  year={1981},
  volume={41 9 Pt 2},
  pages={3761-3}
}
Lithocholic acid, a monohydroxy secondary bile acid, is present in tissues in two forms. One form is extractable with 95% ethanol-0.1% ammonia (soluble lithocholate), and the other form is firmly bound to tissue residues and can be released only by the bile salt-deconjugating enzyme, clostridial cholanoylamino acid hydrolase (tissue-bound lithocholate). Studies on bile salt-protein interactions revealed that lithocholic acid had amino group-modifying activity specifically directed against the… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…