Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease.

@article{Seplveda2014NatureOT,
  title={Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease.},
  author={Fernando J. Sep{\'u}lveda and Humberto Fierro and Eduardo Fern{\'a}ndez and C. Castillo and Robert W. Peoples and Carlos Opazo and L G Aguayo},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 3},
  pages={472-81}
}
The mechanism by which amyloid-β (Aβ) produces brain dysfunction in patients with Alzheimer's disease is largely unknown. According to previous studies, Aβ might share perforating properties with gramicidin, a well-accepted membrane-disrupting peptide. Therefore, we hypothesize that the key steps leading to synaptotoxicity by Aβ and gramicidin involve peptide aggregation, pore formation, and calcium dysregulation. Here, we show that Aβ and gramicidin form aggregates enriched in β-sheet… CONTINUE READING
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