Nature of the effect of caffeine on the drug-metabolizing enzymes.

@article{Mitoma1969NatureOT,
  title={Nature of the effect of caffeine on the drug-metabolizing enzymes.},
  author={Chozo Mitoma and Leon Lombrozo and Susanna E. LeValley and Frank Dehn},
  journal={Archives of biochemistry and biophysics},
  year={1969},
  volume={134 2},
  pages={
          434-41
        }
}
Abstract Pretreatment of the rat for 3 days with caffeine resulted in an elevation in the drugmetabolizing activity by the hepatic microsomal system. This effect is counteracted by the simultaneous administration of actinomycin D. Caffeine also shortened the duration of action of zoxazolamine and methyprylon in the rat. The stimulatory effect of caffeine on drug metabolism was additive to that of phenobarbital when acetanilide was the substrate but not when o -nitroanisole or aminopyrine was… Expand
The effects of xanthines on mouse liver cell
Abstract Pretreatment of mice with caffeine or theophylline for 3 days (100 mg/kg, intraperitoneally, twice daily) resulted in an increase in microsomal protein, RNA content, and cytochrome P-450Expand
The Effect of Daily Ingestion of Caffeine on the Microsomal Enzymes of Rat Liver *
The effect of repeated ingestion of caffeine on rat-liver microsoma Jenzymes was studied. In the rat, ingestion of 20-24 mg caffeine/kg/day in the drinking water for more than 2 wk inhibitedExpand
The effect of daily ingestion of caffeine on the microsomal enzymes of rat liver.
TLDR
Caffeine-treated rats did not respond to the phenobarbitone stimulation of microsomal enzymes to the same extent as did rats treated with phenobarbits alone, and Acetanilide-hydroxylating activity of rat-liver microsoma Jenzymes returned to normal levels at the end of 8 wk. Expand
Effect of caffeine on hepatic microsomal cytochrome P-450.
TLDR
The measurement of ethyl isocyanide difference spectra of dithionite reduced microsomes showed a small but definite increase in the 455-nm peak in the caffeinetreated group, which resembled that of 3-methylcholanthrene. Expand
Effect of caffeine on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo[a]pyrene treatment in rats.
TLDR
No significant difference was seen in the extent of aminopyrine N-demethylase inhibition due to the in vitro addition of caffeine to microsomes from untreated or phenobarbital-treated rats, whereas inhibition in microsome incubations from benzo[a]pyrene- treated rats was greater. Expand
Caffeine increases its own metabolism through cytochrome P4501A induction in rats.
TLDR
Data suggest that caffeine increases its own metabolism through P4501A induction through P4502B dependent catalytic activities determined in vitro. Expand
Effect of methylxanthines on hepatic microsomal enzymes in the rat.
TLDR
Outbred Charles River CD male rats were given one of three methylxanthines (caffeine, theophylline, or theobromine) separately or in combination and microsomal enzyme activity was dependent on the length of treatment and on the time of the determination after the last administration. Expand
Kinetics of caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes.
TLDR
Single metabolites showed different degrees of induction at non-saturating concentrations of caffeine and kinetics was non-linear in CO microsomes. Expand
Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene.
TLDR
It is suggested that caffeine is a moderately poor substrate for the cytochromes P-450 present in control and phenobarbital-pretreated rats, but a particularly good substrates for the form(s) induced by 3-methylcholanthrene. Expand
[2-14C]caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography.
Theobromine, theophylline, paraxanthine and 1,3,7-trimethyluric acid were identified as caffeine metabolites after incubation of [2-14C]caffeine with rat liver microsomes and separation byExpand
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Evidence is presented that phenobarbital induces the synthesis of these enzymes and stimulates liver protein synthesis, and administration of certain drugs enhances the ability of liver microsomes to metabolize the same or a closely related cornpound. Expand
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The extracted microsomes, particularly of the rabbit, were less sensitive to the inhibitory action by SKF 525-A in the metabolism of o -nitroanisole, and attempts to prepare a solubilized enzyme system from the isooctane-treated microsome were not successful. Expand
Pharmacological implications of microsomal enzyme induction.
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The in vitro metabolism of zoxazolamine by TPN fortified liver homogenates has been described and it was found that the administration of 3,4-benzpyrene to rats markedly stimulates the activity of the enzyme system in liver which metabolizes zoxzolamine. Expand
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TLDR
A sensitive method for the estimation of caffeine in biological material is described and it is shown that although a considerable amount of caffeine accumulates in the body of moderately heavy coffee drinkers during the day, there is no day to day accumulation of the drug. Expand
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Sex differences in drug oxidase activity of liver microsomes from rats have been shown to be related to a difference in substrate affinity for the mixed function oxidase reaction, and not to aExpand
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
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The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment. Expand
Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes
TLDR
Hepatic lipids, smooth endoplasmic reticulum, and the activities of drug-metabolizing enzymes were increased with the adequate diet but more so with the deficient one, which may explain the increased tolerance by alcoholics of drugs such as sedatives. Expand
STUDIES ON THE MECHANISM OF ACTION OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE ON STEROID HYDROXYLATIONS IN ADRENAL HOMOGENATES,
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