Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium.

Abstract

The monomer to oligomer transition initiates the aggregation and pathogenic transformation of Alzheimer amyloid-β (Aβ) peptide. However, the monomeric state of this aggregation-prone peptide has remained beyond the reach of most experimental techniques, and a quantitative understanding of this transition is yet to emerge. Here, we employ single-molecule… (More)
DOI: 10.1074/jbc.M110.199885

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