Nature of the Scrapie Agent: Self-replication and Scrapie

  title={Nature of the Scrapie Agent: Self-replication and Scrapie},
  author={J. Stanley Griffith},
Controlling the Structure and Length of Self-Synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly.
Results show that self-synthesizing materials, through their interplay between dynamic covalent bonds and noncovalent interactions, are uniquely suited for out-of-equilibrium self-assembly. Expand
Living supramolecular polymerization realized through a biomimetic approach
This work presents an ‘artificial infection’ process in which porphyrin-based monomers assemble into nanoparticles, and are then converted into nanofibres in the presence of an aliquot of the nan ofibre, which acts as a ‘pathogen’. Expand
Stereoselective Primary and Secondary Nucleation Events in Multicomponent Seeded Supramolecular Polymerization.
  • Souvik Sarkar, Aritra Sarkar, Arka Som, Sarit S. Agasti, Subi J George
  • Medicine
  • Journal of the American Chemical Society
  • 2021
This work presents an unprecedented molecular chirality control on the primary and secondary nucleation events in seed-induced supramolecular polymerization, and reveals the remarkable effect of stereoselective nucleation and seeding events on the (micro)structural aspects of the resulting multicomponent supramolescular polymers. Expand
Chapter 16 - Biology and Medicine
Publisher Summary Spontaneous nucleation centers are often polycrystalline and unsuitable for growing single crystals. For proteins, the nucleation of crystals may compete with the formation ofExpand
Thermo-kinetic model for Prion diseases
A mean field theory of the auto catalytic Prions conversion reaction is developed under a conservation law for Prions density. These reactions take place in the brain where a normally folded PrionExpand
A Molecular Replication Process Drives Supramolecular Polymerization.
  • Yuanning Feng, D. Philp
  • Medicine
  • Journal of the American Chemical Society
  • 2021
A hydrogen-bonded polymer assembled from a bifunctional monomer composed of two replicating templates separated by a rigid spacer is designed, demonstrating that the approach described here is a valid one for the construction of supramolecular polymers and can be extended to systems where the rigid spacers are replaced by one carrying additional function. Expand
The kinetics of proteinase K digestion of linear prion polymers
  • J. Masel, V. Jansen
  • Medicine, Chemistry
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1999
The theoretical kinetics of this model, which hypothesizes that prions are nucleated, macroscopically linear polymers, were investigated and derived predictions which could be used to test the model were derived. Expand
Quasihomogeneous nucleation of amyloid beta yields numerical bounds for the critical radius, the surface tension, and the free energy barrier for nucleus formation.
A reproducible saturation concentration and a critical dependence of various aspects of the aggregation process on this saturation concentration are observed, which supports the applicability of the nucleation theory to Abeta aggregation. Expand
Kinetics of prion growth.
The theoretical results agree with experimental data, whereas the generally accepted hypothesis of constant monomer concentration leads to a fibril growth behavior which is not in agreement with experiments. Expand


A Self-reproducing Analogue
THE most striking peculiarity of living organisms is their property of self-reproduction. The most elementary forms, virus or phage particles, can reproduce themselves in favourable circumstancesExpand
Experimental Scrapie in the Mouse
The disease was transmissible, using a variety of routes in mice, and cases of scrapie developed in goats inoculated with the mouse material, which was filterable, has a high resistance to heat and was demonstrated in the brain and in other tissues. Expand
The exceptionally small size of the scrapie agent.
Teleonomic mechanisms in cellular metabolism, growth, and differentiation.
  • J. Monod, F. Jacob
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 1961