Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera

@article{Evans2007NatureON,
  title={Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera},
  author={Robert W. Evans and Roozina Rafique and A Zarea and Chiara Rapisarda and Richard Cammack and Patricia J. Evans and John B. Porter and Robert C Hider},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2007},
  volume={13},
  pages={57-74}
}
Despite its importance in iron-overload diseases, little is known about the composition of plasma non-transferrin-bound iron (NTBI). Using 30-kDa ultrafiltration, plasma from thalassemic patients consisted of both filterable and non-filterable NTBI, the filterable fraction representing less than 10% NTBI. Low filterability could result from protein binding or NTBI species exceeding 30 kDa. The properties of iron citrate and its interaction with albumin were therefore investigated, as these… CONTINUE READING

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