Nature of functional estrogen receptors at the plasma membrane.

  title={Nature of functional estrogen receptors at the plasma membrane.},
  author={Ali Pedram and Mahnaz Razandi and Ellis Robert Levin},
  journal={Molecular endocrinology},
  volume={20 9},
Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-binding proteins. In endothelial cells (ECs) from ERalpha/ERbeta combined-deleted mice, estradiol (E2… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 221 extracted citations

Membrane estrogen receptors - is it an alternative way of estrogen action?

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2013
View 6 Excerpts
Highly Influenced

Chaperones for proper androgen action - a plethora of assistance to androgen receptor function.

Hormone molecular biology and clinical investigation • 2012
View 8 Excerpts
Highly Influenced

Estrogen Regulation of MicroRNA Expression

Current genomics • 2009
View 9 Excerpts
Highly Influenced

Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium.

Toxicology and applied pharmacology • 2008
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 48 references

Integration of the extra-nuclear and nuclear actions of estrogen

ER Levin
Mol Endocrinol • 2005

Similar Papers

Loading similar papers…