Nature of allelic sequence polymorphism at the KIR3DL3 locus

  title={Nature of allelic sequence polymorphism at the KIR3DL3 locus},
  author={Des C. Jones and Susan E. Hiby and Ashley Moffett and John Trowsdale and Neil T. Young},
KIR3DL3 is a framework gene of the Leukocyte Receptor Complex, present in all individuals and haplotypes analysed to date. We describe 17 novel KIR3DL3 alleles, including seven single nucleotide polymorphic (SNP) positions within the coding region. Sequence variation within introns included a VNTR within intron 1. As KIR3DL3 mRNA is known to be expressed in decidual NK cells, we investigated the impact of KIR3DL3 allelic variation on pre-eclampsia. No statistical difference in allele frequency… CONTINUE READING


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