Nature and biological significance of DNA modification by the haloethylnitrosoureas.

@article{Ludlum1986NatureAB,
  title={Nature and biological significance of DNA modification by the haloethylnitrosoureas.},
  author={David B. Ludlum},
  journal={IARC scientific publications},
  year={1986},
  volume={78},
  pages={71-81}
}
The haloethylnitrosoureas are both successful antitumour agents and laboratory carcinogens. A growing body of evidence suggests that their biological activities result from DNA modification. By decomposing in different ways, the haloethylnitrosoureas generate intermediates that can introduce either hydroxyethyl or haloethyl groups into DNA. One hydroxyethyl derivative, O6-hydroxyethylguanine, may be responsible for at least some of the carcinogenicity of these compounds. Haloethyl derivatives… CONTINUE READING