Naturally produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells

@article{Ivanov2007NaturallyPE,
  title={Naturally produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells},
  author={Vadim Ivanov and Svetlana Ivanova and Mohd Waheed Roomi and Tatiana Kalinovsky and Aleksandra Niedzwiecki and Matthias Rath},
  journal={Medical Oncology},
  year={2007},
  volume={24},
  pages={209-217}
}
Enhanced supplementation with certain naturally occurring nutrients and vitamins has been associated with a reduction in occurrence and progression of human cancer. The exact mechanisms of this action are still under investigation. Extracellular matrix (ECM) plays a key role in the development of cancer. Therefore, we studied whether nutrients could exert anticancer effects through alteration of ECM biological properties. Confluent cultures of normal human dermal fibroblasts were allowed to… 
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