Naturally processed non-canonical HLA-A*02:01 presented peptides.

@article{Hassan2015NaturallyPN,
  title={Naturally processed non-canonical HLA-A*02:01 presented peptides.},
  author={Chopie Hassan and Eric Chabrol and Lorenz Jahn and Michel G. D. Kester and Arnoud H. de Ru and Jan Wouter Drijfhout and Jamie Rossjohn and J H Frederik Falkenburg and Mirjam H M Heemskerk and Stephanie Gras and Peter A. van Veelen},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 5},
  pages={2593-603}
}
Human leukocyte antigen (HLA) class I molecules generally present peptides (p) of 8 to 11 amino acids (aa) in length. Although an increasing number of examples with lengthy (>11 aa) peptides, presented mostly by HLA-B alleles, have been reported. Here we characterize HLA-A*02:01 restricted, in addition to the HLA-B*0702 and HLA-B*4402 restricted, lengthy peptides (>11 aa) arising from the B-cell ligandome. We analyzed a number of 15-mer peptides presented by HLA-A*02:01, and confirmed pHLA-I… CONTINUE READING

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