Naturally prion resistant mammals: a utopia?

@article{FernndezBorges2012NaturallyPR,
  title={Naturally prion resistant mammals: a utopia?},
  author={Natalia Fern{\'a}ndez-Borges and Francesca Chianini and Hasier Era{\~n}a and Enric Vidal and Samantha L. Eaton and Bel{\'e}n Pintado and Jeanie Finlayson and Mark P. Dagleish and Joaqu{\'i}n Castilla},
  journal={Prion},
  year={2012},
  volume={6 5},
  pages={425-9}
}
Each known abnormal prion protein (PrP (Sc) ) is considered to have a specific range and therefore the ability to infect some species and not others. Consequently, some species have been assumed to be prion disease resistant as no successful natural or experimental challenge infections have been reported. This assumption suggested that, independent of the virulence of the PrP (Sc) strain, normal prion protein (PrP (C) ) from these 'resistant' species could not be induced to misfold. Numerous in… CONTINUE READING
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