Naturally occurring somatostatin and vasoactive intestinal peptide inhibitors. Isolation of alkaloids from two marine sponges.

  title={Naturally occurring somatostatin and vasoactive intestinal peptide inhibitors. Isolation of alkaloids from two marine sponges.},
  author={Aude Vassas and G Bourdy and J J Paillard and Jacques Lavayre and Mary Pa{\"i}s and Jean Charles Quirion and C{\'e}cile Debitus},
  journal={Planta medica},
  volume={62 1},
The vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor, SRIF) are important neurotransmitters in a number of basic physiological events. Their disturbances have been reported in many diseases such as cystic fibrosis, impotent man (VIP), Alzheimer's disease, and some tumours (SRIF). Xestospongine B (1), sceptrine (2), and ageliferine (3), three alkaloids isolated from Xestospongia sp. and Agelas novaecaledoniae are reported as somatostatin and VIP… Expand
Chapter 21. Non-peptide Somatostatin Receptor Ligands
This chapter provides an overview of non-peptide somatostatin receptor ligands and predicts that medicinal chemistry efforts will continue to develop potent, selective and orally bioavailable agents for each of the receptor subtypes. Expand
Marine bromopyrrole alkaloids: synthesis and diverse medicinal applications.
In this review detailed account of isolation and medicinal application of marine bromopyrrole alkaloids and their synthetic derivatives are discussed. Expand
In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa
The first chemical study of the secondary metabolites of the sponge A. dilatata from the coastal area of the Yucatan Peninsula (Mexico) is reported, confirming bromoageliferin as a potential lead for designing new antibacterial drugs. Expand
Isolation of Araguspongine M, a New Stereoisomer of an Araguspongine/Xestospongin alkaloid, and Dopamine from the Marine Sponge Neopetrosia exigua Collected in Palau
A new stereoisomer of an araguspongine/xestospongin alkaloid, named araguspongine M (1), has been isolated together with 12 known compounds, araguspongines B (2) and D (3), dopamine, three galactosylExpand
Natural Products from Sponges
Development of recombinant microorganisms engineered for efficient production of sponge-derived products is a promising strategy that deserves further attention in future investigations in order to address the limitations regarding sustainable supply of marine drugs. Expand
Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine Sponges
Natural products isolated from marine organism such as sponges, fungi and bacteria show a unique structural diversity which may lead to new metabolites which can be used for medicinal purposes. Expand
Sceptrin, a Marine Natural Compound, Inhibits Cell Motility in a Variety of Cancer Cell Lines
It is reported for the first time that sceptrin inhibits cell motility in several cancer cell lines and could prove to be an attractive lead molecule for further preclinical testing and development for therapeutic purposes, as well as a useful research tool to elucidate the mechanisms involved incell motility. Expand
Bioactive cyclobutane-containing alkaloids
  • V. Dembitsky
  • Biology, Medicine
  • Journal of Natural Medicines
  • 2007
Research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species, confirmed to show antimicrobial, antibacterial, anticancer, and other activities are described. Expand
A Submarine Journey: The Pyrrole-Imidazole Alkaloids †
This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products. Expand
Bioactive natural products from marine sources
This article deals principally with bioactive constituents characterized in the past decade from marine sources in order to obtain a better understanding of the biological significance of marine flora and fauna. Expand