Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.

@article{Carroll2011NaturallyOS,
  title={Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.},
  author={Ronan K Carroll and Samuel A. Shelburne and Randall Olsen and Bryce Suber and Pranoti V Sahasrabhojane and Muthiah Kumaraswami and Stephen B Beres and Patrick R. Shea and Anthony R. Flores and James M. Musser},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 5},
  pages={1956-68}
}
Infection with different strains of the same species of bacteria often results in vastly different clinical outcomes. Despite extensive investigation, the genetic basis of microbial strain-specific virulence remains poorly understood. Recent whole-genome sequencing has revealed that SNPs are the most prevalent form of genetic diversity among different strains of the same species of bacteria. For invasive serotype M3 group A streptococci (GAS) strains, the gene encoding regulator of proteinase B… CONTINUE READING

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