Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-naïve patients with chronic hepatitis C

@inproceedings{Costantino2015NaturallyOM,
  title={Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-na{\"i}ve patients with chronic hepatitis C},
  author={Angela Costantino and Enea Spada and Michele Equestre and Roberto Bruni and Elena Tritarelli and Nicola Coppola and Caterina Sagnelli and Evangelista Sagnelli and Anna Rita Ciccaglione},
  booktitle={Virology Journal},
  year={2015}
}
The detection of baseline resistance mutations to new direct-acting antivirals (DAAs) in HCV chronically infected treatment-naïve patients could be important for their management and outcome prevision. In this study, we investigated the presence of mutations, which have been previously reported to be associated with resistance to DAAs in HCV polymerase (NS5B) and HCV protease (NS3) regions, in sera of treatment-naïve patients. HCV RNA from 152 naïve patients (84 % Italian and 16 % immigrants… CONTINUE READING
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