Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse.

  title={Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse.},
  author={Paweł Sachadyn and Xiang-Ming Zhang and Lise Desquenne Clark and Robert K. Naviaux and Ellen Heber-Katz},
  volume={8 5-6},
The MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TPsiC loop of the tRNA methionine gene (tRNA-Met; mt-Tm). The second is a heteroplasmic insertion of 1-6… CONTINUE READING
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