Naturally occurring mitochondrial DNA haplotypes exhibit metabolic differences: insight into functional properties of mitochondria.

@article{Pichaud2012NaturallyOM,
  title={Naturally occurring mitochondrial DNA haplotypes exhibit metabolic differences: insight into functional properties of mitochondria.},
  author={Nicolas Pichaud and J William O Ballard and Robert M Tanguay and Pierre Blier},
  journal={Evolution; international journal of organic evolution},
  year={2012},
  volume={66 10},
  pages={3189-97}
}
Linking the mitochondrial genotype and the organismal phenotype is of paramount importance in evolution of mitochondria. In this study, we determined the differences in catalytic properties of mitochondria dictated by divergences in the siII and siIII haplogroups of Drosophila simulans using introgressions of siII mtDNA type into the siIII nuclear background. We used a novel in situ method (permeabilized fibers) that allowed us to accurately measure the consumption of oxygen by mitochondria in… CONTINUE READING