Naturally occurring human phosphorylcholine antibodies are predominantly products of affinity-matured B cells in the adult.

@article{Fiskesund2014NaturallyOH,
  title={Naturally occurring human phosphorylcholine antibodies are predominantly products of affinity-matured B cells in the adult.},
  author={Roland Fiskesund and Johanna Steen and Khaled Amara and Fiona R. Murray and Agnieszka Szwajda and Anquan Liu and Iyadh Douagi and Vivianne Malmstr{\"o}m and J Frosteg{\aa}rd},
  journal={Journal of immunology},
  year={2014},
  volume={192 10},
  pages={4551-9}
}
Phosphorylcholine (PC) is a classic T-independent Ag that is exposed on apoptotic cells, oxidized phospholipids, and bacterial polysaccharides. Experimental as well as epidemiological studies have over the past decade implicated Abs against PC (anti-PC) as anti-inflammatory and a strong protective factor in cardiovascular disease. Although clinically… CONTINUE READING