Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons.

  title={Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons.},
  author={Catherine S Woolley and Ernie A. Gould and Maya Frankfurt and Bruce S. McEwen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={10 12},
We have used Golgi-impregnated tissue to demonstrate that apical dendritic spine density in CA1 hippocampal pyramidal cells undergoes a cyclic fluctuation as estradiol and progesterone levels vary across the estrous cycle in the adult female rat. We observed a 30% decrease in apical dendritic spine density over the 24-hr period between the late proestrus and the late estrus phases of the cycle. Spine density then appears to cycle back to proestrus values over a period of several days. In… CONTINUE READING
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