Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification.

@article{Osipov2008NaturallyOD,
  title={Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification.},
  author={Alexey V. Osipov and I. E. Kasheverov and Yana V. Makarova and Vladislav G. Starkov and Olga V Vorontsova and Rustam Kh Ziganshin and Tatyana V. Andreeva and Marina V. Serebryakova and Audrey Benoit and Ronald C Hogg and Daniel Bertrand and V. I. Tsetlin and Yuri N Utkin},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 21},
  pages={14571-80}
}
Disulfide-bound dimers of three-fingered toxins have been discovered in the Naja kaouthia cobra venom; that is, the homodimer of alpha-cobratoxin (a long-chain alpha-neurotoxin) and heterodimers formed by alpha-cobratoxin with different cytotoxins. According to circular dichroism measurements, toxins in dimers retain in general their three-fingered folding. The functionally important disulfide 26-30 in polypeptide loop II of alpha-cobratoxin moiety remains intact in both types of dimers… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Disulfide-bound Dimers of Three-fingered Toxins 14580 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • K. Kulkeaw, W. Chaicumpa, Y. Sakolvaree, P. Tongtawe, P. Tapchaisri
  • Toxicon
  • 2007

355–361 Disulfide-bound Dimers of Three-fingered Toxins

  • D. L. Crimmins, M. Saylor, J. Rush, R. S. Thoma
  • Anal. Biochem
  • 1995

Similar Papers

Loading similar papers…