Naturally occurring benzodiazepines: current status of research and clinical implications

@article{Sand2000NaturallyOB,
  title={Naturally occurring benzodiazepines: current status of research and clinical implications},
  author={Philipp G Sand and Dominique Kavvadias and Doris Feineis and Peter Franz Riederer and Peter H. Schreier and M. Kleinschnitz and Franz-C. Czygan and Ahmed A. Abou-Mandour and Gerhard Bringmann and Helmut Beckmann},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2000},
  volume={250},
  pages={194-202}
}
Abstract Naturally occurring benzodiazepines (BZDs) were first detected in mammalian tissues in 1986. They comprise a variety of 1,4-benzodiazepines corresponding to drugs commercially available for the treatment of anxiety disorders, sleep disturbances and epileptic seizures. Several biosynthetic pathways leading to the formation of BZDs are currently being discussed and have led to the proposition of possible precursor molecules.For years, the identification of naturally occurring BZDs in… 
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References

SHOWING 1-10 OF 115 REFERENCES
Naturally occurring benzodiazepines in human milk.
Occurrence of "natural" benzodiazepines.
Benzodiazepines: A Handbook. Basic Data, Analytical Methods, Pharmacokinetics and Comprehensive Literature
To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa rable
Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor
Récepteur des benzodiazépines : l'énigme du ligand endogène
The structure of the benzodiazepine receptor is nowadays well established and its potentialisation of GABA neurotransmission is known as the main action mechanism of benzodiazepinic drugs. Three
Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.
TLDR
Results show that benzodiazepine-like molecules of natural origin--and possibly Benzodiazepines themselves--are present in human and other mammalian brains.
[The benzodiazepine receptor: the enigma of the endogenous ligand].
The structure of the benzodiazepine receptor is nowadays well established and its potentialisation of GABA neurotransmission is known as the main action mechanism of benzodiazepinic drugs. Three
Formation of benzodiazepine-like molecules in rat brain.
Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy
TLDR
Endogenous benzodiazepines may accumulate in patients with liver cirrhosis during the course of the disease, and the phenomenon appears to be independent of the presence or absence of encephalopathy.
...
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