Naturally occurring antihormones: secretion of FSH antagonists by women treated with a GnRH analog.

@article{Dahl1988NaturallyOA,
  title={Naturally occurring antihormones: secretion of FSH antagonists by women treated with a GnRH analog.},
  author={K. D. Dahl and Thomas A. Bicsak and Aaron J Hsueh},
  journal={Science},
  year={1988},
  volume={239 4835},
  pages={72-4}
}
Follicle-stimulating hormone (FSH) is a glycoprotein essential for gonadal development and steroidogenesis. Recent studies suggest that deglycosylation of FSH results in the formation of antagonistic proteins that are capable of binding to gonadal receptors but that are devoid of bioactivity. Treatment of hypogonadal women with an antagonist of gonadotropin-releasing hormone substantially decreased serum FSH bioactivity with minimal changes in immunoreactivity. Chromatofocusing and size… CONTINUE READING

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