Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver.

@article{Faioni1993NaturallyOA,
  title={Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver.},
  author={Elena M. Faioni and A Krachmalnicoff and Scott I. Bearman and Augusto B Federici and Adriano Decarli and Alessandro Massimo Gianni and George B McDonald and Pier Mannuccio Mannucci},
  journal={Blood},
  year={1993},
  volume={81 12},
  pages={3458-62}
}
Venocclusive disease (VOD) of the liver is the major dose-limiting complication of pretransplant regimens for bone marrow transplantation. Recent reports from different groups point to the involvement of the hemostatic mechanism in the development of VOD. We measured the naturally occurring anticoagulants protein C, antithrombin III, and protein S in 45 patients undergoing bone marrow transplantation for hematologic malignancies before cytoreductive therapy and after transplant. The aim of this… CONTINUE READING
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Clift RA: Veno-occlusive disease of the liver and multi-organ failure following marrow transplantation: A cohort study of 355 patients

  • GB McDonald, MS Hinds, +5 authors HM Shulman
  • Ann Intern Med
  • 1993

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