Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.

@article{Kuniyasu2000NaturallyAA,
  title={Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.},
  author={Yoshio Kuniyasu and Takeshi Takahashi and Mizue Itoh and Jun-ya Shimizu and Gotaro Toda and Shimon Sakaguchi},
  journal={International immunology},
  year={2000},
  volume={12 8},
  pages={
          1145-55
        }
}
A CD4(+) T cell subpopulation defined by the expression levels of a particular cell surface molecule (e.g. CD5, CD45RB, CD25, CD62L or CD38) bears an autoimmune-preventive activity in various animal models. Here we show that the expression of CD25 is highly specific, when compared with other molecules, in delineating the autoimmune-preventive immunoregulatory CD4(+) T cell population. Furthermore, although CD25 is an activation marker for T cells, the following findings indicate that… CONTINUE READING

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