Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.

@article{Bricard2005NaturallyAM,
  title={Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.},
  author={Gabriel Bricard and Hanifa Bouzour{\`e}ne and Olivier Martinet and Donata Rimoldi and Nermin Halkic and Michel Gillet and Pascal Chaubert and H Robson Macdonald and Pedro Romero and J C Cerottini and Daniel E Speiser},
  journal={Journal of immunology},
  year={2005},
  volume={174 3},
  pages={1709-16}
}
Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specific for two cancer-testis (CT) Ags (MAGE-A1 and MAGE-A3) in tumor infiltrating lymphocytes of HCC… CONTINUE READING