Naturally Occurring Plant Coumarins

  title={Naturally Occurring Plant Coumarins},
  author={Robert D. H. Murray},
Over the past 150 years, since Vogel in 1820 isolated the parent oxygen heterocycle, coumarin (1) from Coumarouna odorata = Dipteryx odorata (1), coumarins have been recognized as widely distributed plant products. The vast majority carry an oxygen substituent at C-7; consequently 7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex… 
Medicinal Potential and Biosynthesis of Plant Coumarins
Coumarins comprise a large group of natural compounds isolated from many plant or microbial sources, and novel derivatives are still being reported each year, but the mechanism of coumarin biosynthesis has been resolved only partially and significant progress has been accomplished recently.
Progress in the Chemistry of Naturally Occurring Coumarins.
  • S. Sarker, L. Nahar
  • Chemistry, Medicine
    Progress in the chemistry of organic natural products
  • 2017
Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects.
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
Activities and Novel Applications of Secondary Metabolite Coumarins
ABSTRACT This review covers biological activity of secondary metabolites, coumarin and their derivatives on different organisms (pests, pathogens, weeds), as well as their applications in agriculture
Coumarins — An Important Class of Phytochemicals
There may be as many as 4,000 different phytochemicals having potential activity against several diseases such as cancer and metabolic or degenerative diseases, but not all are established as essential nutrients.
Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties
This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.
Coumarins: Plants, structure, properties
The second chapter of the review contains information on 330 coumarins, arranged in Russian alphabetical order, with the names of the producing plants, structures, properties, melting points,
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida
It is shown that gerbera plants transformed with the gene for 2PS in an antisense orientation and unable to synthesise gerberin and parasorboside are susceptible to Botrytis cinerea infection.
Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo.
  • H. Kolodziej
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2007
These Pelargoniums have thus represented an attractive source of fascinating secondary metabolites and a notable wealth of highly oxygenated simple coumarins and a number of miscellaneous uncommon metabolites.
Functional characterization of a Mg(2+)-dependent O-methyltransferase with coumarin as preferred substrate from the liverwort Plagiochasma appendiculatum.
The catalytic capacities of the studied protein suggest that two routes to scopoletin might co-exist in liverworts in that the enzyme involved in the methylation process participates in both paths, but especially the route from esculetin.


Coumarin-hemiterpene ethers from Artemisia species
Five new coumarin-hemiterpene ethers were isolated from the leaves of Artemisia laciniata, A. armeniaca and A. tanacetifolia and identified by 1H and 13C NMR spectroscopy, characterized particularly by compounds with a hydroxylated and saturated isoprenoid unit attached to oxygen at the C-8 position.
New Coumarins from Citrus Plants
Four new coumarins, named peroxytamarin (1), cis-casegravol (5), citrusarin-A (7), and citrusarin-B (8), were isolated from root of Citrus plants and their structures were elucidated by chemical and
New Coumarins from Some Citrus Plants
Six new coumarins, 6-formylumbelliferone (1), hassanon (2), 5-hydroxyseselin (4), cis-grandmarin (6, cis), trans-grandmarin isovalerate (8, trans), and kinocoumarin (9), were isolated from roots and
Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii.
Investigation of the MeOH extracts of Sargentia greggii (Rutaceae) led to the isolation of two known flavones and a new flavone, 5,6,2',3',4',6'-hexamethoxyflavone, whose structure was established by spectral data and confirmed by total synthesis.
Coumarins from Aster praealtus
Abstract Chemical analysis of aerial parts and roots of Aster praealtus provided, besides the known coumarins umbelliferone, marmin, epoxyaurapten and 6′-hydroxy-β-cycloaurapten, four new 7- O
Isolation of New Constituents from Citrus Plants
A new coumarin and a new acridone-coumarin dimer named trans-grandmarin (1) and acrimarine-H (5), respectively, were isolated from roots of some Citrus plants (Rutaceae) and their structures are
Prenylated coumarins and sesquiterpenoids from Ferula communis
Abstract From the latex of Ferula communis , two 4-hydroxycoumarin derivatives were isolated bearing a farnesylic and a 12-hydroxyfarnesylic residue, respectively, at C-3. Prenylated coumarins, which
Extractives of Dalea species (Leguminosae)
Abstract Coumarin(4), 5-methoxycoumarin(5) and two deep red pigments have been isolated from the extracts of Dalea emoryi. The two pigments, dalrubone and methoxydalrubone differ by a single OMe
Biosynthetic studies in the coumarin series—II : Studies in plants of Thamnosma montana Torr. and Frem. The role of acetate and glycine☆
Abstract The role of sodium acetate-[2- 14 C] and glycine-[2- 14 C] in the biosynthesis of the coumarins, umbelliprenin ( 1 ), isopimpinellin ( 2 ) and alloimperatorin methyl ether ( 3 ) has been
[Studies on the constituents of Murraya paniculata (L) Jack].
  • J. Yang, Y. Su
  • Chemistry, Medicine
    Yao xue xue bao = Acta pharmaceutica Sinica
  • 1983
Hainanmurpanin, a new coumarin, was isolated from the leaves and branches of Murraya paniculata (L.) Jack. (Rutaceae) grown in Hainan. On the basis of spectral (UV, IR, NMR and MS) analyses and