Naturally-Occurring Neospora caninum Infection in an Adult Sheep and Her Twin Fetuses

  title={Naturally-Occurring Neospora caninum Infection in an Adult Sheep and Her Twin Fetuses},
  author={Y. Kobayashi and Makoto Yamada and Yoshitaka Omata and T Koyama and Atsushi Saito and Tadashi Matsuda and Kazuhiko Okuyama and Seiichiro Fujimoto and Hidefumi Furuoka and T. Matsui},
  booktitle={The Journal of parasitology},
Neospora caninum tissue cysts were found in the brains of surgically delivered twin fetuses at 119 days of gestation. In the brains of both fetuses, there was an inflammatory reaction involving perivascular cuffings of mononuclear cells, glial nodules. The dam of these fetuses died because of metritis. Histopathological examination of the ewe revealed N. caninum tissue cysts and focal gliosis with mononuclear cell cuffings. A N. caninum-specific DNA fragment was detected in a brain homogenate… Expand
Neospora caninum in sheep: a herd case report.
Neospora caninum was detected by means of PCR in the brain of 4 out of 20 aborted fetuses in a flock of 117 sheep exhibiting a persistent abortion problem, and N. caninum tissue cysts wereExpand
Isolation of Neospora caninum From the Brain of a Pregnant Sheep
Neospora caninum was isolated from the brain of a naturally infected pregnant sheep by inoculation of immunodeficient mice with a homogenate of the brain tissue. The ewe showed no clinical signs.Expand
Transplacental transmission of Neospora caninum to lambs in successive pregnancies of naturally infected sheep in Southern Brazil.
The detection of N. caninum DNA in a newborn lamb with neurological signs and congenital neosporosis and in a stillborn lamb, both born from the same ewe in a herd of Southern Brazil, is reported. Expand
The first report of ovine cerebral neosporosis and evaluation of Neospora caninum prevalence in sheep in New South Wales.
Although the diagnosis of fatal ovine cerebral neosporosis is of importance to the surveillance program for transmissible spongiform encephalopathy (TSE) exclusion, sheep in NSW are not commonly infected with N. caninum and this species likely plays only a minor role in the life cycle of this parasite in Australia. Expand
The present review attempts to summarize both the known information and the views about the life cycle of the parasite, the pathogenesis and clinical signs of the disease, the mechanisms of transmission, the diagnostic methods and the means of infection control. Expand
Maternal immune response in the placenta of sheep during recrudescence of natural congenital infection of Neospora caninum.
It is suggested that, similarly to bovine neosporosis, the time of gestation when recrudescence occurs determines the viability of the fetuses and, thus, seems to be related to the severity of lesions and immune response in the placenta. Expand
Ovine Abortion by Neospora caninum: First Case Reported in Argentina
For the first time, a natural case of ovine abortion associated with Neospora caninum is described in a flock with reproductive losses in Argentina and N.Caninum DNA was detected in placenta, central neural system, lung and heart of the aborted fetus and there was no evidence of other infectious abortifacients in the abortedetus. Expand
The comparative pathogenesis of neosporosis.
How Neospora invades cells, how it infects and causes disease in several animal species, and particularly how it has evolved a special niche in cattle and dogs that ensures its survival are discussed. Expand
Review of Neospora caninum and neosporosis in animals.
  • J. Dubey
  • Biology, Medicine
  • The Korean journal of parasitology
  • 2003
Information on biology, diagnosis, epidemiology and control of neosporosis in animals, a major cause of abortion in cattle in many countries, is reviewed. Expand
Redescription of Neospora caninum and its differentiation from related coccidia
Neospora caninum is a protozoan parasite of animals, which before 1984 was misidentified as Toxoplasma gondii. Infection by this parasite is a major cause of abortion in cattle and causes paralysisExpand


Fatal congenital Neospora caninum infection in a lamb.
Neospora caninum tissue cysts were found in the brain and spinal cord of a 1-wk-old lamb that was unable to stand after birth. The lamb was originally diagnosed as having toxoplasmosis, butExpand
The pathogenesis of experimental neosporosis in pregnant sheep.
Immunohistochemical examination showed that the parasite had invaded the placentas of all cases examined, displaying an apparent predilection for fetal chorionic epithelium and fetal placental blood vessels, as well as inducing thrombosis in some maternal caruncular blood vessels. Expand
Experimental Neosporosis in Pregnant Ewes and Their Offspring
Diagnosticians should carefully distinguish between neosporosis and toxoplasmosis in cases of ovine protozoal abortion unless future investigations exclude the likelihood of naturally acquired neOSporosis in sheep. Expand
Experimental infection of non-pregnant and pregnant sheep with Neospora caninum.
N. caninum readily infected pregnant ewes and caused lesions in fetal tissues and placentas which resembled those of ovine toxoplasmosis, which offers a good model for the bovine disease. Expand
A review of Neospora caninum and neosporosis.
Neospora caninum is a recently recognized protozoan parasite of animals, which until 1988 was misidentified as Toxoplasma gondii. Its life cycle is unknown. Transplacental transmission is the onlyExpand
Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances.
  • D. Buxton
  • Biology, Medicine
  • Veterinary research
  • 1998
The protozoan parasite Toxoplasma gondii is a serious cause of fetal mortality in sheep and goats. Oocysts, the parasite stage responsible for initiating infection, are produced following a primaryExpand
Neospora Caninum Induced Abortion in Sheep
  • J. Dubey, D. Lindsay
  • Medicine
  • Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 1990
The respiratory infection in these bulls may have predisposed them to the iron intoxication and should increase the susceptibility to parenterally administered iron intoxication. Expand
Identification of Toxoplasma gondii infections by BI gene amplification
PCR can be considered a valuable additional tool for the identification of T. gondii infections because it is a sensitive, relatively rapid, and specific method and because it can be applied to a variety of different clinical samples. Expand
Antibody reactivity in mice and cats to feline enteroepithelial stages of Toxoplasma gondii.
Results suggest that FES parasites may have stage-specific antigen(s), and mice immunized with feline enteroepithelial stage (FES) parasites produced antibodies not only against FES, but also against tachyzoites, sporozoites/oocysts, tissue cysts and one part of the infected feline enterocytes. Expand
Neospora caninum: specific oligonucleotide primers for the detection of brain "cyst" DNA of experimentally infected nude mice by the polymerase chain reaction (PCR).
The results indicate that PCR with the primer pair Np21/Np6 could provide an efficient tool for large-scale epidemiological studies using brain tissue obtained at necropsy. Expand