Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.

@article{Lawson2015NaturallyOI,
  title={Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.},
  author={Ann P. Lawson and Marcus J.C. Long and Rory T Coffey and Yu Qian and Eranthie Weerapana and Farid El Oualid and Lizbeth Hedstrom},
  journal={Cancer research},
  year={2015},
  volume={75 23},
  pages={5130-5142}
}
The anticancer properties of cruciferous vegetables are well known and attributed to an abundance of isothiocyanates such as benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC). While many potential targets of isothiocyanates have been proposed, a full understanding of the mechanisms underlying their anticancer activity has remained elusive. Here we report that BITC and PEITC effectively inhibit deubiquitinating enzymes (DUB), including the enzymes USP9x and UCH37, which are… CONTINUE READING
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References

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Showing 1-10 of 53 references

Discovery of Therapeutic Deubiquitylase Effector Molecules: Current Perspectives.

Journal of biomolecular screening • 2014
View 10 Excerpts
Highly Influenced

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes.

Chembiochem : a European journal of chemical biology • 2012
View 5 Excerpts
Highly Influenced

Parkin directly modulates 26S proteasome activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 10 Excerpts
Highly Influenced

SK.Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, KimB, KimSH, Srivastava
Mol Nutr Food Res • 2014
View 4 Excerpts
Highly Influenced

Ubiquitination in disease pathogenesis and treatment

Nature Medicine • 2014
View 4 Excerpts
Highly Influenced

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