Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1.

@article{Park2011NaturalVE,
  title={Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1.},
  author={Han-A Park and Natalia Kubicki and Surya C. Gnyawali and Yuk Cheung Chan and Sashwati Roy and Savita Khanna and Chandan K. Sen},
  journal={Stroke},
  year={2011},
  volume={42 8},
  pages={2308-14}
}
BACKGROUND AND PURPOSE α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against stroke in vivo. Elevation of intracellular oxidized glutathione (GSSG) triggers neural cell death. Multidrug resistance-associated protein 1 (MRP1), a key mediator of intracellular oxidized glutathione efflux… CONTINUE READING
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