Natural variation of histone modification and its impact on gene expression in the rat genome.

  title={Natural variation of histone modification and its impact on gene expression in the rat genome.},
  author={Carola Rintisch and Matthias Heinig and Anja Bauerfeind and Sebastian Schafer and Christin Mieth and Giannino Patone and Oliver Hummel and Wei Yea Chen and Stuart A. Cook and Edwin Cuppen and Maria Colom{\'e}-Tatch{\'e} and Frank Johannes and Ritsert C. Jansen and Helen Neil and Michel Werner and Michal Pravenec and Martin Vingron and Norbert Hubner},
  journal={Genome research},
  volume={24 6},
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. Little is known about interindividual variability of histone modification levels across the genome and to what extent they are influenced by genetic variation. We annotated the rat genome with histone modification maps, identified differences in histone trimethyl-lysine levels among strains, and described their underlying… CONTINUE READING
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