Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.

@article{Ackerman2013NaturalVI,
  title={Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.},
  author={Margaret E. Ackerman and Max Crispin and Xiaojie Yu and Kavitha Baruah and Austin W Boesch and David J. Harvey and A Dugast and Erin L Heizen and Altan Ercan and Ickwon Choi and Hendrik Streeck and Peter A Nigrovic and Chris Bailey-Kellogg and Chris Scanlan and Galit Alter},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 5},
  pages={2183-92}
}
While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible to induce antibodies with enhanced Fc effector activity and improved antiviral control via vaccination. However, the specific features of naturally induced HIV-specific antibodies that allow for the potent recruitment of antiviral activity and the means by which these functions are regulated are poorly… CONTINUE READING

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Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1

  • CM Karsten
  • Nat Med
  • 2012
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