Natural type I interferon-producing cells as a link between innate and adaptive immunity.

@article{Kadowaki2002NaturalTI,
  title={Natural type I interferon-producing cells as a link between innate and adaptive immunity.},
  author={Norimitsu Kadowaki and Yong-Jun Liu},
  journal={Human immunology},
  year={2002},
  volume={63 12},
  pages={1126-32}
}
Type I interferons (IFNs) are promptly produced upon invasion of pathogens, and activate a broad range of effector cells in the innate and adaptive immune system. Lin(-)CD4(+)CD11c(-) plasmacytoid dendritic cell precursors (plasmacytoid pre-DCs) produce enormous amounts of type I IFNs in response to viruses and CpG DNA, thus corresponding to the previously described but not fully defined natural type I IFN-producing cells (IPCs). Plasmacytoid pre-DCs strongly express toll-like receptor (TLR) 7… CONTINUE READING

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