Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system.

@article{Hofreuter2001NaturalTC,
  title={Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system.},
  author={Dirk Hofreuter and Stefan Odenbreit and Rainer Haas},
  journal={Molecular microbiology},
  year={2001},
  volume={41 2},
  pages={379-91}
}
Helicobacter pylori (Hp), a Gram-negative bacterial pathogen and aetiologic agent of gastroduodenal disease in humans, is naturally competent for genetic transformation. Natural competence in bacteria is usually correlated with the presence of type IV pili or type IV pilin-like proteins, which are absent in Hp. Instead, we recently identified the comB operon in Hp, carrying four genes tentatively designated as orf2, comB1, comB2 and comB3. We show here that all ComB proteins and the 37-amino… CONTINUE READING
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