Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance.

@article{Savi2009NaturalST,
  title={Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance.},
  author={Sne{\vz}ana D Savi{\'c} and Christian Weber and Miroslav M. Savi{\'c} and Christel Charlotte M{\"u}ller-Goymann},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={381 2},
  pages={
          220-30
        }
}
View on PubMed
doi.org
44 Citations
Background Citations
12
Methods Citations
4
Results Citations
3

44 Citations

NEW NATURAL SUGAR-BASED SURFACTANTS INTENDED FOR STABILIZATION OF COSMETIC/DERMOPHARMACEUTICAL VEHICLES – SAFETY AND EFFICACY ASSESSMENT

Investigating the most frequently used APG, that emulsions based on these emulsifiers could probably be promoted as safe cosmetic/ dermopharmaceutical vehicles showed an excellent skin moisturizing capacity which is essential in maintaining healthy skin, but also in improving dermatitis, which follows most pathological skin conditions.

N EW NATURAL SUGAR-BASED SURFACTANTS INTENDED FOR STABILIZATION OF COSMETIC/DERMOPHARMACEUTICAL VEHICLES - SAFETY AND EFFICACY ASSESSMENT

Investigating the most frequently used APG, that emulsions based on these emulsifiers could probably be promoted as safe cosmetic/ dermopharmaceutical vehicles showed an excellent skin moisturizing capacity, which is essential in maintaining healthy skin, but also in improving dermatitis, which follows most pathological skin conditions.

An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: the influence of colloidal structure on emulsions skin hydration potential.

Studies on Improving Solubility in Different Media for Said Formulations with Topical Application

The solubilization tests performed for pharmaceutical compounds of the NSAID class in different hydrophilic media are presented and help in choosing solvents in the formulation and technologicalization of semi-solid preparations with topical application.

Critical quality attributes, in vitro release and correlated in vitro skin permeation-in vivo tape stripping collective data for demonstrating therapeutic (non)equivalence of topical semisolids: A case study of "ready-to-use" vehicles.

From conventional towards new – natural surfactants in drug delivery systems design: current status and perspectives

Recent FDA certification of an alkyl polyglucoside surfactant for topical formulation presents a significant step in the process of recognition of this relatively new group of surfactants, which could trigger further research into the potential benefits of naturally derived materials in both conventional and new drug delivery systems.

Stability and In Vitro Skin Compatibility of an Adapalene-Loaded Solid Lipid Microparticle Dispersion

A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion composed of topically approved ingredients exhibited follicular penetration and a targeted drug release in sebum. In the present…

Residual film formation after emulsion application: understanding the role and fate of excipients on skin surface.

Systematic Investigation of the Effect of Non-Ionic Emulsifiers on Skin by Confocal Raman Spectroscopy—A Comprehensive Lipid Analysis

It is possible to characterize the molecular effects of non-ionic emulsifiers on skin lipids and further deepen the understanding of enhancing substance penetration with reduced skin barrier properties and increased lipid fluidity.

Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle, and LA per se and in APG‐based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin.

References

SHOWING 1-10 OF 33 REFERENCES

An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: the influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation.

Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation.

Functions of mixed emulsifiers and emulsifying waxes in dermatological lotions and creams

In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug.

Comparative permeation studies for delta-aminolevulinic acid and its n-butylester through stratum corneum and artificial skin constructs.

  • A. WinklerC. Müller-Goymann
  • Chemistry, Medicine
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2002

Vehicle-controlled effect of urea on normal and SLS-irritated skin.

Use of artificial skin constructs in permeation studies of clindamycin phosphate.

Higher drug permeabilities were achieved with ASC in comparison with excised human stratum corneum (EHSC) and the running time of the experiments could be reduced in the case of ASC because of higher permeation coefficients obtained.

Structure and drug release of lamellar liquid crystals containing glycerol.

Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption.

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

The RHE models, EPISKIN, EpiDerm and SkinEthic, are appropriate alternatives to human and pig skin, for the in vitro assessment of the permeation and penetration of substances when applied as aqueous solutions.