Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.

Abstract

BACKGROUND Nuclear accumulation of p53 protein in breast cancer cells is generally accepted as a marker for the presence of p53 gene mutation and as an indicator of poor prognosis. Mutation in the p53 gene has been shown to cause conformational change in the p53 protein, which gives rise to a complex with heat shock protein 70 (hsp70). EXPERIMENTAL DESIGN… (More)

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Cite this paper

@article{Iwaya1995NaturalSO, title={Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.}, author={K Iwaya and Hitoshi Tsuda and Shigeru Fujita and M Suzuki and Setsuo Hirohashi}, journal={Laboratory investigation; a journal of technical methods and pathology}, year={1995}, volume={72 6}, pages={707-14} }