Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells


Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it also recycles nutrients to maintain energy… (More)
DOI: 10.1038/srep05510
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