Natural selection shaped regional mtDNA variation in humans

@article{Mishmar2002NaturalSS,
  title={Natural selection shaped regional mtDNA variation in humans},
  author={D. Mishmar and E. Ruiz-Pesini and P. Golik and V. Macaulay and A. Clark and S. Hosseini and M. Brandon and Kirk A Easley and Estella Chen and Michael D. Brown and R. Sukernik and A. Olckers and D. Wallace},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={100},
  pages={171 - 176}
}
Human mtDNA shows striking regional variation, traditionally attributed to genetic drift. However, it is not easy to account for the fact that only two mtDNA lineages (M and N) left Africa to colonize Eurasia and that lineages A, C, D, and G show a 5-fold enrichment from central Asia to Siberia. As an alternative to drift, natural selection might have enriched for certain mtDNA lineages as people migrated north into colder climates. To test this hypothesis we analyzed 104 complete mtDNA… Expand
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