Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila.

@article{Comeron1999NaturalSO,
  title={Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila.},
  author={Josep M. Comeron and Martin Kreitman and Montserrat Aguad{\'e}},
  journal={Genetics},
  year={1999},
  volume={151 1},
  pages={239-49}
}
Evolutionary analysis of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are subject to weak selection at the translation level. Here we show that the effectiveness of natural selection on synonymous sites is strongly correlated with the rate of recombination, in accord with the nearly neutral hypothesis. This correlation, however, is apparent only in genes encoding short proteins. Long coding regions have both a lower codon bias and higher synonymous… CONTINUE READING
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