Natural selection on human microRNA binding sites inferred from SNP data

@article{Chen2006NaturalSO,
  title={Natural selection on human microRNA binding sites inferred from SNP data},
  author={Kevin Y Chen and Nikolaus Rajewsky},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1452-1456}
}
A fundamental problem in biology is understanding how natural selection has shaped the evolution of gene regulation. Here we use SNP genotype data and techniques from population genetics to study an entire layer of short, cis-regulatory sites in the human genome. MicroRNAs (miRNAs) are a class of small noncoding RNAs that post-transcriptionally repress mRNA through cis-regulatory sites in 3′ UTRs. We show that negative selection in humans is stronger on computationally predicted conserved miRNA… CONTINUE READING
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 232 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…