Natural selection of tumor variants in the generation of “tumor escape” phenotypes


The idea that tumors must “escape” from immune recognition contains the implicit assumption that tumors can be destroyed by immune responses either spontaneously or as the result of immunotherapeutic intervention. Simply put, there is no need for tumor escape without immunological pressure. Here, we review evidence supporting the immune escape hypothesis… (More)
DOI: 10.1038/ni1102-999


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