Natural selection in the TLR-related genes in the course of primate evolution

Abstract

The innate immune system constitutes the front line of host defense against pathogens. Toll-like receptors (TLRs) recognize molecules derived from pathogens and play crucial roles in the innate immune system. Here, we provide evidence that the TLR-related genes have come under natural selection pressure in the course of primate evolution. We compared the… (More)
DOI: 10.1007/s00251-008-0332-0

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Cite this paper

@article{Nakajima2008NaturalSI, title={Natural selection in the TLR-related genes in the course of primate evolution}, author={Toshiaki Nakajima and Hitoshi Ohtani and Yoko Satta and Yasuhiro Uno and Hirofumi Akari and Takafumi Ishida and Akinori Kimura}, journal={Immunogenetics}, year={2008}, volume={60}, pages={727-735} }